About Dr. Hufeng Zhou


Research Interests

  • Exploring the fundamental epigenetic mechanisms of EBV associated Cancers, using Next-Generation Sequencing technologies, including Whole Genome/Exome Sequencing (WGS/WES), ChIP-Seq, RNA-seq, ATAC-seq, GRO-seq, HiC, ChIA-PET, 4C-seq, etc.

  • Investigate EBV Super-Enhancers regulatory effects through non-coding RNA (ncRNA) especially Enhancer RNA(eRNAs) and long-range interactions (ChIA-PET and 4C-seq) and build a comprehensive eRNA regulatory network that plays important role in the formation of EBV associated lymphomas. And I am also working on the Enhancers’ and Super Enhancers’ regulation on microRNAs through long-range interactions.

  • Use 3D genomics (HiC and ChIA-PET) and Functional Information (Gene Ontology and Pathway) to identify the disease-related variants (SNPs, INDELs, CNVs, etc.) from common variants, and illuminate how they influence the gene expressions and phenotype through integrative genomics and machine learning strategies.

  • Besides, Dr. Zhou also have years of research experiences in Protein-Protein Interactions (PPI) related studies; Pathway data integration and analysis; Human-Microbiome Metagenomic data analysis; data mining and machine learning application on clinical data, software and databases development based on these research areas. The experience in PPI and pathway networks serves as important source of creativity in his current genomic/epigenomic research.


Work Experience

  • Harvard Medical School and Brigham and Woman's Hospital, Boston, U.S.A, Junior Faculty Member (Instructor), Since July. 2015 (current position). Supervisor: Prof. Elliott Kieff (retired in March 2017).

  • Harvard Medical School and Brigham and Woman's Hospital, Boston, U.S.A, Postdoctoral Research Fellow, Jan. 2013 – July. 2015. Supervisor: Prof. Elliott Kieff.



  • National University of Singapore (Asia’s best University consistently ranked No. 1 by QS World University Rankings and Times Higher Education World University Rankings), Singapore, Ph. D. in Computational Biology, School of Computing and NUS Graduate School for Integrative Sciences & Engineering, GPA: 4.82/5.0, July 2009-June 2013. Supervisor: Prof. Limsoon Wong.


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